have always had a penchant for poking fun at campmates on , but while their humorous banter rarely misses the mark, this can't be said for all situations.
The presenters are known far and wide for their quick-witted jests and sharp commentary, just as much as their empathetic ears and comforting support when times get tough for the contestants.
Ant and Dec have remained a core part of the series since it first kicked off in 2002, with it simply impossible to imagine without them.
However, despite their playful personalities, they've not always clicked right away with all the stars they meet.
Ahead of Ant and Dec's return to I'm A Celeb, Express.co.uk have looked back at some of their most memorable run-ins with celebs from over the years.
The iconic pair found themselves in an enduring spat with famously outspoken broadcaster Piers Morgan, who didn't hold back when they scooped their 20th Best Presenter award in a row at the 2021 National Television Awards.
A fuming Piers lashed out at Ant and Dec, proclaiming: "I deserve to win because everyone is sick and tired of Ant and Dec automatically winning this award, which bears no relation to reality. They've done nothing special in the last year, even they would admit that."
Piers lambasted the presenters as "little vain-glorious Geordies" and took particular issue with Ant's accolade considering his period of absence, decrying it as "ridiculous".
Their rivalry was recently rekindled following their BAFTA victory, where they received the Best Entertainment award for their show Saturday Night Takeaway, much to the chagrin of Piers, reports .
They humorously remarked that they must be "doing something right" upon learning that the 59-year-old was displeased with their success, while Ant expressed delight at his annoyance.
Many fans have speculated about a possible feud between Ant and 2008's I'm A Celeb winner Joe Swash due to occasional icy remarks. However, according to the duo, this is not the case.
During an episode of the show's spin-off series Extra Camp in 2017, the hosts sat down with Swash for some clarification on the awkward topic.
Dec mentioned that he had "read online" about a supposed "beef" between them and queried if it was "genuine". In response, Joe sarcastically said: "No, I just think there's a fine line between not liking someone and finding them very horny."
Ant then humorously claimed that he was "sexually attracted" to the former actor and proceeded to embrace him.
However, when Joe attempted to kiss him, the pair started a mock argument with Ant telling him he had gone "too far" and "ruined the moment", pushing him back onto the couch.
Joe then shouted for Ant to "just kiss him" because he had "embarrassed him in front of the nation," but the whole charade seemed in good spirits.
The 42-year-old then begged Ant to "just kiss him" as he had "embarrassed him in front of the nation," but the entire spectacle appeared to be in good fun.
Mysterious Girl hitmaker Peter Andre once lived beneath Ant and Dec and reminisced about the days when he threw raucous parties in his West London flat, causing the boys to "bang on the ceiling" in frustration.
He recounted: "My apartment was right above PJ and Duncan's. They used to bang their brooms on the ceiling late at night because I had parties all the time. This was before they were Ant and Dec, before they were TV gods, and had just done Let's Get Ready To Rhumble."
Reflecting on how times have changed, Peter noted that "life has changed" as he observed Ant and Dec heading to an afterparty while he chose to go home, feeling he was "went back home because he was over it".
Model and presenter Kelly Brook also had a history with the Geordie pair.
She attributed a negative impact on her career to Ant and Dec following their remarks about her brief stint as a judge on Britain's Got Talent in 2009.
After being on the show for less than a week, Ant and Dec commented that she was "wrong from the start", which led Kelly to believe they were being duplicitous.
Speaking on Heart FM, the 44-year-old said: "Do you know what, having worked on Britain's Got Talent for all of three days, I kind of know what happens.
Simon [Cowell] calls you. He basically makes you an offer you can't refuse. You kind of say, 'Look I don't know what this show's all about, I've never seen the show.'
"Then you go on it, he falls out with you and you get the sack. All he's got to do is not ask Ant and Dec what they do on the show. That was my mistake."
Despite past tensions, it seems bridges have been mended as Ant and Dec were seen enjoying themselves at Steam and Rye, the cocktail bar co-owned by Kelly and her business partner Nick House, a few years later.
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